Granville Lab Publications
Hiroyasu S, Turner, CT, Richardson, DC, Granville DJ. Proteases in Pemphigoid Diseases. Frontiers in Immunology, vol. 10, 2019, pp. 1454–1454.
Zeglinski MR, Turner CT, Zeng R, Schwartz C, Santacruz S, Pawluk MA, Zhao H, Chan AW, Carlsten C, Granville DJ. Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway. Scientific Reportsvolume 9, Article number: 10027 (2019).
Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM. Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation. Proc Natl Acad Sci U S A 2019.
Turner CT, Lim D, Granville DJ. Granzyme B in skin inflammation and disease. Matrix Biology 2019; 75-76: 126-40.
Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner CT, Granville DJ, Lefebvre L, Plotnikov S, Goult BT, Tanentzapf G. Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo. Cell Rep 2018; 25(9): 2401-16 e5.
Sellers SL, Turner CT, Sathananthan J, Cartlidge TRG, Sin F, Bouchareb R, Mooney J, Norgaard BL, Bax JJ, Bernatchez PN, Dweck MR, Granville DJ, Newby DE, Lauck S, Webb JG, Payne GW, Pibarot P, Blanke P, Seidman MA, Leipsic JA. Tanentzapf G. Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration. JACC Cardiovasc Imaging 2018. In press.
Turner CT, Zeglinski MR, Richardson KC, Zhao H, Shen Y, Papp A, Bird PI, Granville DJ. Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling. Journal of Investigative Dermatology 2018. In press.
Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke C-W, Overall CM, Granville DJ. Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction. Scientific Reports 2018; 8(1): 9690.
Shen Y, Zeglinski MR, Turner CT, Raithatha SA, Wu Z, Russo V, Oram C, Hiroyasu S, Nabai L, Zhao H, Bozin T, Westendorf K, Kopko I, Huang R, Arns S, Tan J, Zeng H, Boey A, Liggins R, Jaquith J, Cameron DR, Papp A, Granville DJ. Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing. Experimental & Molecular Medicine 2018; 50(5): 68.
Shen Y, Russo V, Zeglinski MR, Sellers SL, Wu Z, Oram C, Santacruz S, Merkulova Y, Turner C, Tauh K, Zhao H, Bozin T, Bohunek L, Zeng H, Seidman MA, Bleackley RC, McManus BM, Ruoslahti E, Järvinen TAH, Granville DJ. Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture. Scientific Reports 2017; 7(1): 15857.
Arias M, Martínez-Lostao L, Santiago L, Ferrandez A, Granville DJ, Pardo J. The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances. Trends Cancer. 2017: 3(6):407-422
Merkulova Y, Shen Y, Parkinson LG, Raithatha SA, Zhao H, Westendorf K, Sharma M, Bleackley RC, Granville DJ. Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signalling. Biol Chem. 2016: 397(9):883-95.
Sharma M, Merkulova Y, Raithatha S, Parkinson LG, Shen Y, Cooper D, Granville DJ. Extracellular Granzyme K Mediates Endothelial Activation Through the Cleavage of Protease Activated Receptor-1 (PAR-1). FEBS J. 2016: 283(9):1734-47.
Shen Y, Cheng F, Sharma M, Merkulova Y, Raithatha SA, Parkinson LG, Zhao H, Westendorf K, Bohunek L, Bozin T, Hsu I, Ang LS, Williams SJ, Bleackley RC, Eriksson JE, Seidman MA, McManus BM, Granville DJ. Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis. Am J Pathol. 2016: 186(1):87-100.
Hanson P, Ye X, Qiu Y, Zhang H, Hemida M, Wang F, Lim T, Gu A, Cho B, Kim H, Fung G, Granville DJ*, Yang D*. Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES containing genes. Cell Death Differ. (2016)
Sharma A, Sellers S, Stefanovic N, Leung C, Tan SM, Huet O, Granville DJ, Cooper ME, de Haan JB, Bernatchez P. 2015 Direct eNOS activation provides atheroprotection in diabetes-accelerated atherosclerosis. Diabetes.
Leigh G. Parkinson, Ana Toro, Hongyan Zhao, Keddie Brown, Scott J. Tebbutt and David J. Granville. 2015 Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-lose ultraviolet light irradiation. Aging Cell.
Hsu I, Parkinson LG, Shen Y, Toro A, Brown T, Zhao H, Bleackley RC, Granville DJ. 2014Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing. Cell death and disease.
Hendel A, Hsu I, Granville DJ. 2014. Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability. Lab Investigation.
Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nature medicine.
Hiebert PR, Boivin WA, Zhao H, McManus BM, Granville DJ. 2013. Perforin and Granzyme B Have Separate and Distinct Roles during Atherosclerotic Plaque Development in Apolipoprotein E Knockout Mice. PLoS One.
Hiebert PR, Wu D, Granville DJ. 2013. Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice. Cell Death Differ.
Hirota JA, Hiebert PR, Gold M, Wu D, Graydon C, Smith JA, Ask K, McNagny K, Granville DJ, Knight DA. 2013. Granzyme B Deficiency Exacerbates Lung Inflammation in Mice Following Acute Lung Injury. Am J Respir Cell Mol Biol.
Hendel A, Granville DJ. 2012. Granzyme B Cleavage of Fibronectin Disrupts Endothelial Cell Adhesion, Migration and Capillary Tube Formation. Matrix Biol.
Hiebert PR, Granville DJ. 2012. Granzyme B in injury, inflammation, and repair. Trends Mol Med. 18(12):732-41
Hendel A, Ang LS, Granville DJ. 2012. Inflammaging and Proteases in Abdominal Aortic Aneurysm. Curr Vasc Pharmacol.
Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM. 2012. Inflammation in myocardial diseases. Circ Res 110: 126-44
Ang LS, Boivin WA, Williams SJ, Zhao H, Abraham T, Carmine-Simmen K, McManus BM, Bleackley RC, Granville DJ. 2011. Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm. Cell Death Dis 2: e209
Cooper DM, Pechkovsky DV, Hackett TL, Knight DA, Granville DJ. 2011. Granzyme K activates protease-activated receptor-1. PLoS One 6: e21484
Hiebert PR, Boivin WA, Abraham T, Pazooki S, Zhao H, Granville DJ. 2011. Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice. Exp Gerontol 46: 489-99
Hendel A, Cooper D, Abraham T, Zhao H, Allard MF, Granville DJ. 2011. Proteinase inhibitor 9 is reduced in human atherosclerotic lesion development. Cardiovasc Pathol 21: 28-38
Chamberlain CM, Ang LS, Boivin WA, Cooper DM, Williams SJ, Zhao H, Hendel A, Folkesson M, Swedenborg J, Allard MF, McManus BM, Granville DJ. 2010. Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol 176: 1038-49
Granville DJ. 2010. Granzymes in disease: bench to bedside. Cell Death Differ 17: 565-6
Hendel A, Hiebert PR, Boivin WA, Williams SJ, Granville DJ. 2010. Granzymes in age-related cardiovascular and pulmonary diseases. Cell Death Differ 17: 596-606
Boivin WA, Cooper DM, Hiebert PR, Granville DJ. 2009. Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma. Lab Invest 89: 1195-220
Hunter AL, Kerjner A, Mueller KJ, McManus BM, Granville DJ. 2008. Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy. Am J Transplant 8: 1631-8
Rahmani M, Cruz RP, Granville DJ, McManus BM. 2006. Allograft vasculopathy versus atherosclerosis. Circ Res 99: 801-15
Choy JC, Cruz RP, Kerjner A, Geisbrecht J, Sawchuk T, Fraser SA, Hudig D, Bleackley RC, Jirik FR, McManus BM, Granville DJ. 2005. Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. Am J Transplant 5: 494-9
Gustafsson AB, Gottlieb RA, Granville DJ. 2005. TAT-mediated protein transduction: delivering biologically active proteins to the heart. Methods Mol Med 112: 81-90
Choy JC, Hung VH, Hunter AL, Cheung PK, Motyka B, Goping IS, Sawchuk T, Bleackley RC, Podor TJ, McManus BM, Granville DJ. 2004. Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol 24: 2245-50
Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P, Jr., Yeager M, Gottlieb RA. 2004. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A 101: 1321-6
