The Granville Lab

Welcome

From the University of British Columbia in the beautiful city of Vancouver Canada, our group is focused on researching the role of granzymes in inflammation and disease. Here you will find information about our current research, the people who conduct this research and the fun things we like to do beyond our research.

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Events

The Granville Lab is pleased to host the next D.R.I.N.K.S. on Wednesday, January 22 from 4pm to 6:30pm. We will adhere to the PHO safety recommendations and follow all precautions required by the restaurant. Look forward to seeing you there!

Background

The D.R.I.N.K.S. (Discussions Relevant to Inspiring New Knowledge and Science) social, now called BioConnect BC, is held monthly at Mahoneys on Stamps Landing (Old Monk Mcqueens on False Creek at 601 Stamps Landing - http://mahonyandsons.com/). The purpose is to bring together faculty, clinicians, scientists, residents, trainees, staff, entrepreneurs, bio/pharm staff/execs/veterans, lawyers, VCs, and others with common interests in biomedical/translational research & discovery/commercialization once a month to casually interact and meet new people over a beverage of their choice and/or appie. It's also becoming a great way for people that have just moved to, or even just visiting Vancouver to meet others in research/biomedical field/industry. All are welcome to sign up on the LinkedIn page.

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Recent publications

December 2024Science around the world. Trends Mol Med.
October 2024Granzyme B cleaves Tenascin-C to release its C-Terminal domain in rheumatoid arthritis. JCI Insight.	August 2024Granzymes in Aging and Age-Related Pathologies. Trends in Molecular Medicine.
July 2024Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration. Front. Immunol.	June 2024Granzyme K mediates IL-23 Inflammation and Keratinocyte Proliferation in Psoriasis. Frontiers in Immunology.
May 2024Granzyme Serine Proteases in Inflammation and Rheumatic Diseases. Nature Rev. Rheumatol.	May 2024Granzyme research supercharges medical advancements for autoimmune and age-related chronic diseases. Vancouver Coastal Health Research Institute.
April 2024Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization. Angiogenesis.	February 2024Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation - PubMed (nih.gov). J. Periodontal Res.
April 2023NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection. Cell Rep.	March 2023Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration through Proteolysis of Thrombospondin-1. Lab Invest.
February 2023Granzyme B in Autoimmune Skin Disease. Biomolecules.	January 2023Granzyme K contributes to microvascular dysfunction and leakage during skin inflammation. Br J Dermatol.
January 2023Granzyme B as a therapeutic target: an update in 2022. Expert Opin Ther Targets.	September 2022Potential role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy - PubMed (nih.gov) Front. Pharmacol.
August 2022Implications of SM22α-Cre expression in keratinocytes and un-anticipated inflammatory skin lesions in a model of atherosclerosis. American Jounral of Physiology.	August 2022Sulfaphenazole reduces thermal and pressure injury severity through rapid restoration of tissue perfusion. Scientic Reports.
July 2022Non-cytotoxic roles of granzymes in health and disease. Physiology.	April 2022Granzyme B in Epithelial Barrier Dysfunction and Related Skin Diseases. American Journal of Physiology.
March 2022γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release. Gastroenterology.	November 2021 Pathological functions of granzyme B in inflammatory skin diseases. Journal of Dermatological Science.
August 2021 Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge.	March 2021 Granzyme B mediated impaired healing in pressure injuries in aged skin. Nature Aging Mech Dis.
January 2021 Granzyme B inhibition reduces disease severity in autoimmune blistering diseases. Nature Comm.	January 2021 Granzyme B Induces IRF-3 Phosphorylation through a Perforin-Independent Proteolysis-Dependent Signaling Cascade without Inducing Cell Death. J. Immunol.
October 2020 Granzymes in Cardiovascular Injury and Disease.	July 2020 Tricuspid Valve-in-Valve and Bioprosthetic Surgical Tricuspid and Pulmonic Valve Degeneration: Lessons From Imaging and Histopathology.
June 2020 Granzyme B contributes to barrier dysfunction in oxazolone-induced skin inflammation through E-cadherin and filaggrin cleavage.	June 2020 Key enzyme that contributes to eczema identified.
June 2020 Researchers uncover novel approach for treating eczema.	April 2020 Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins.
February 2020 Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.	February 2020 Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm.
September 2019 Granzyme B as a therapeutic target for wound healing. Expert Opin Ther Targets.	July 2019 Proteases in Pemphigoid Diseases. Front. Immunol.
July 2019Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway. Scientific Reports.	February 2019 Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation. PNAS.
January 2019Granzyme B in skin inflammation and disease. Matrix Biol.	November 2018 Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration. JACC Cardiovasc Imaging
November 2018Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo. Cell Reports.	November 2018 Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling. J Invest Dermatol.
June 2018Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction. Scientific Reports.	May 2018Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing. Exp Mol Med.
November 2017Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture. Scientific Reports	June 2017 The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances. Trends Cancer.
May 2016 Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1. FEBS J.	February 2016 Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis. Am J Pathol.
February 2015 Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation. Aging Cell.	May 2014 A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med.

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